22 July 2014

Isradipine group of calcium channel blockers

Isradipine is a group of drugs called calcium channel blockers. Isradipine works by relaxing the heart muscle and blood vessels. These drugs are sometimes used with other blood pressure medications.

Indications:
To treat high blood pressure (hypertension).

Dosage:
The release of regular:
Initial dose: 2.5 mg by mouth (orally)
May be increased to 5 mg by mouth (orally), 2 times daily, after 3-4 weeks

Extended release:
5 mg by mouth (orally), 1 times daily.

Side Effects:

  1. CV effects (decreased cardiac function, hypotension, heart failure is getting worse, edema, skin redness, bradycardia), GI effects (constipation); CNS effects (headache, dizziness).

  2. HR regulate calcium antagonists (Diltiazem, Gallopamil & Verpamil) AV dissociation, AV block, bradycardia, and sinus stem dysfunction.

Short-acting dihydropyridine agents should be avoided because it has the potential to increase the risk of adverse cardiac events.

Special Instructions:
There will be contraindicated in patients who clearly have decompensated HR, although vasoselective dihydropyrBidine (eg Amlodipine and HR which regulates calcium antagonist that there will be contraindicated in patients with bradycardia, sinus stem dysfunction, and AV nodal block.

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