Showing posts with label Channel Blocker. Show all posts
Showing posts with label Channel Blocker. Show all posts

13 June 2011

Lacidipine Type Calcium Channel Blocker Drug

Description:
Lacidipine is a group of type calcium channel blocker drug. Lacidipine works by relaxing the heart muscle and blood vessels.

Indications:
To treat high blood pressure (hypertension).

Dosage:

  • The initial dose: 2 mg by mouth (orally), 1 times daily

  • May be increased to 4 mg, if necessary to 6 mg by mouth (orally), 1 time a day after at least 3-4 weeks away.

Side Effects:

  • CV effects (decreased cardiac function, hypotension, heart failure is getting worse, edema, skin redness, bradycardia), GI effects (constipation); CNS effects (headache, dizziness).

  • HR regulate calcium antagonists (Diltiazem, Gallopamil & verapamil); AV dissociation, AV block, bradycardia, and sinus stem dysfunction.

  • Short-acting dihydropyridine agents should be avoided because it has the potential to increase the risk of adverse cardiac events.

Special Instructions:

  • Contraindicated in patients who clearly have decompensated HR, although vasoselective dihydropyridine (eg Amlodipine and Felodipine) can be accepted by patients with reduced LV solution.

  • HR which regulates calcium antagonists contraindicated in patients with bradycardia, sinus stem dysfunction, and AV nodal block.