Showing posts with label hyponatremia. Show all posts
Showing posts with label hyponatremia. Show all posts

25 September 2013

Chlorthalidone: The type of thiazide diuretic drugs

Chlorthalidone is a thiazide-type diuretic medicine (water pill) that helps prevent the body from excessive salt absorption, which can cause fluid retention (edema).

Indications:
To treat fluid retention (edema) in people with congestive heart failure (CHF), cirrhosis of the liver, kidney disorders, or edema caused by the use of steroids and estrogen.
To treat high blood pressure (hypertension).

Dosage:
25-100 mg by mouth (orally), 1 time a day.
Maximum dose: 200 mg / day

Side Effects:
Endocrine and metabolic effects (hiperuricemia and can cause gout in some patients, hypochloremic alkalosis, hyponatremia, hypokalemia, hipomagnesemia, hyperglycemia & glycosuria in patients with diabetes mellitus or other vulnerable); Effects of GI (GI irritation, N / V, constipation, anorexia, diarrhea), CNS effects (headache, dizziness); Other effects (photosensitivity reactions, postural hypotension, impotence, hypersensitivity reactions).
Signs of electrolyte imbalance: headache, muscle cramps, dry mouth, hypotension, thirst, fatigue, drowsiness, and so on.

Special Instructions:
Do not use thiazide if GFR (glomerular filtration rate) less than 30 ml / min except when used synergistically with loop diuretics.

Avoid in patients who have fluid & electrolyte imbalance or in those at risk of fluid & electrolyte imbalance (eg parents), patients with liver cirrhosis is more likely to develop hypokalemia, and patients with acute heart failure is more likely to suffer from hyponatremia, use with caution in patients kidney damage, use with caution in patients suspected of having gout and diabetes mellitus. Monitor the patient for signs of fluid and electrolyte imbalance.