Candesartan Drugs for Hypertension

Description:
Candesartan is a group of drugs called angiotensin II receptor antagonists. Candesartan keep blood vessels from narrowing, which reduces blood pressure and improve blood flow. Candesartan sometimes given in conjunction with other blood pressure medications.

Indications:
To treat high blood pressure (hypertension).

Dosage:

1. The initial dose: 4 mg by mouth (orally), 1 times daily


2. Increase dose with ambiguous times lipatkan dose until the highest dose that can be accepted patients, at a distance of more than 2 weeks.


3. Target dose: 32 mg by mouth (orally), 1 times daily.

Side Effects:

1. Usually settled and mild: CNS effects (dizziness); Effects of CV (orthostatic hypotension associated with dose, which may occur particularly in patients who lack the volume); kidney damage.


2. Other effects are somewhat rare: rash, angioedema, raised LFTs (liver function tests); myalgia.

Special Instructions:

1. Patients who lack the volume (eg high-dose diuretic therapy) may experience hypotension and should start with low doses.


2. Use with caution in patients with renal artery stenosis, kidney damage or liver damage.


3. Check your blood pressure (BP), renal function and electrolytes 1-2 weeks after the addition of each dose, at 3 months and then do every 6 months. (It takes more control in patients with previous or new experience renal dysfunction).

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Chlorthalidone: The type of thiazide diuretic drugs

Chlorthalidone is a thiazide-type diuretic medicine (water pill) that helps prevent the body from excessive salt absorption, which can cause fluid retention (edema).

Indications:
To treat fluid retention (edema) in people with congestive heart failure (CHF), cirrhosis of the liver, kidney disorders, or edema caused by the use of steroids and estrogen.
To treat high blood pressure (hypertension).

Dosage:
25-100 mg by mouth (orally), 1 time a day.
Maximum dose: 200 mg / day

Side Effects:
Endocrine and metabolic effects (hiperuricemia and can cause gout in some patients, hypochloremic alkalosis, hyponatremia, hypokalemia, hipomagnesemia, hyperglycemia & glycosuria in patients with diabetes mellitus or other vulnerable); Effects of GI (GI irritation, N / V, constipation, anorexia, diarrhea), CNS effects (headache, dizziness); Other effects (photosensitivity reactions, postural hypotension, impotence, hypersensitivity reactions).
Signs of electrolyte imbalance: headache, muscle cramps, dry mouth, hypotension, thirst, fatigue, drowsiness, and so on.

Special Instructions:
Do not use thiazide if GFR (glomerular filtration rate) less than 30 ml / min except when used synergistically with loop diuretics.

Avoid in patients who have fluid & electrolyte imbalance or in those at risk of fluid & electrolyte imbalance (eg parents), patients with liver cirrhosis is more likely to develop hypokalemia, and patients with acute heart failure is more likely to suffer from hyponatremia, use with caution in patients kidney damage, use with caution in patients suspected of having gout and diabetes mellitus. Monitor the patient for signs of fluid and electrolyte imbalance.

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