Description:
Cefixime is a semisynthetic antibiotic cephalosporin class. Is bakterisid by inhibiting cell wall synthesis. Cefixime is active against gram-positive microorganisms such as Streptococcus sp. Streptococcus pneumoniae and gram-negative microorganisms such as Haemophilus influenza, Moraxella (Branhamella) catarrhalis, Escherichia coli and Proteus sp. Infix has a high stability of b-lactamase produced by micro-organisms and good activity against b-lactamase produced by microorganisms.
Cefixime is distributed into the sputum, tonsils, sinus maxillaris mucosa, secretions from the ear, bile, gallbladder tissue, vesicle fluid and fluid prosta t. Cefixime is excreted primarily through the kidneys. Nothing found antibacterial active metabolite in human serum or urine.
Composition:
Infix 100, each capsule contains cefixime100 mg.
Indications:
Infix is indicated to treat infections caused by sensitive strains ikroorganisme like this:
Mild urinary tract infection caused by Escherichia coli and Proteus mirabilis.
Otitis media caused by Haemophilus influenzae (strains b-lactamase positive and negative), Moraxella (Branhamella) catarrhalis (b-lactamase positive) and Streptococcus pyogenes.
Pharyngitis and Tonsillitis caused by Streptococcus pyogenes.
Acute bronchitis and "acute exacerbations of chronic bronchitis" caused by Streptococcus pneumoniae and Haemophilus influenzae (strains b-lactamase positive and negative).
Dosage:
Adults and children with body weight ³ 30 kg: capsules or suspensions, 50 - 100 mg, 2 times daily.
Dose adjusted for age, weight and condition of the patient.
For severe infection: dose increased to 200 mg, 2 times daily.
Patients with kidney failure: Dose and frequency of administration depends on the severity.
Adults with creatinine clearance between 21 and 60 ml / min or in patients who undergo renal hemodialysis: The dose given was 75% of the standard dose (ie 300 mg daily at intervals of as usual).
Adults with creatinine clearance less than 20 ml / min or in patients who undergo "continuous ambulatory peritoneal dyalisis" (CAPD): The dose given was 50% of the standard dose (ie 200 mg daily at intervals of as usual).
In acute overdose: do flushing the stomach, because there is no specific antidotum. Cefixime is not substantially removed by hemodialysis or peritoneal dialysis.
Children with body weight <30 kg
Suspension: daily dose in infants is 1.5 to 3 mg / kg body weight given 2 times daily as orally.
For more severe infections, dosage should be increased to 6 mg / kg body weight given 2 times daily.
In children, otitis media should be given treatment in the suspension dosage forms. Clinical studies of otitis media has been associated with suspension and the results showed that the preparations for the suspension to give blood peak levels higher than the tablet dosage form at the same dose. Therefore, the suspension should not be replaced with other dosage forms in the treatment of otitis media.
Cefixime is a semisynthetic antibiotic cephalosporin class. Is bakterisid by inhibiting cell wall synthesis. Cefixime is active against gram-positive microorganisms such as Streptococcus sp. Streptococcus pneumoniae and gram-negative microorganisms such as Haemophilus influenza, Moraxella (Branhamella) catarrhalis, Escherichia coli and Proteus sp. Infix has a high stability of b-lactamase produced by micro-organisms and good activity against b-lactamase produced by microorganisms.
Cefixime is distributed into the sputum, tonsils, sinus maxillaris mucosa, secretions from the ear, bile, gallbladder tissue, vesicle fluid and fluid prosta t. Cefixime is excreted primarily through the kidneys. Nothing found antibacterial active metabolite in human serum or urine.
Composition:
Infix 100, each capsule contains cefixime100 mg.
Indications:
Infix is indicated to treat infections caused by sensitive strains ikroorganisme like this:
Mild urinary tract infection caused by Escherichia coli and Proteus mirabilis.
Otitis media caused by Haemophilus influenzae (strains b-lactamase positive and negative), Moraxella (Branhamella) catarrhalis (b-lactamase positive) and Streptococcus pyogenes.
Pharyngitis and Tonsillitis caused by Streptococcus pyogenes.
Acute bronchitis and "acute exacerbations of chronic bronchitis" caused by Streptococcus pneumoniae and Haemophilus influenzae (strains b-lactamase positive and negative).
Dosage:
Adults and children with body weight ³ 30 kg: capsules or suspensions, 50 - 100 mg, 2 times daily.
Dose adjusted for age, weight and condition of the patient.
For severe infection: dose increased to 200 mg, 2 times daily.
Patients with kidney failure: Dose and frequency of administration depends on the severity.
Adults with creatinine clearance between 21 and 60 ml / min or in patients who undergo renal hemodialysis: The dose given was 75% of the standard dose (ie 300 mg daily at intervals of as usual).
Adults with creatinine clearance less than 20 ml / min or in patients who undergo "continuous ambulatory peritoneal dyalisis" (CAPD): The dose given was 50% of the standard dose (ie 200 mg daily at intervals of as usual).
In acute overdose: do flushing the stomach, because there is no specific antidotum. Cefixime is not substantially removed by hemodialysis or peritoneal dialysis.
Children with body weight <30 kg
Suspension: daily dose in infants is 1.5 to 3 mg / kg body weight given 2 times daily as orally.
For more severe infections, dosage should be increased to 6 mg / kg body weight given 2 times daily.
In children, otitis media should be given treatment in the suspension dosage forms. Clinical studies of otitis media has been associated with suspension and the results showed that the preparations for the suspension to give blood peak levels higher than the tablet dosage form at the same dose. Therefore, the suspension should not be replaced with other dosage forms in the treatment of otitis media.
0 comments:
Post a Comment