What is tamadol?
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Tramadol is a centrally acting synthetic analgesic of the aminocyclohexanol group with opioid-like effects. Its mode of action is not completely understood but it appears to act by modifying transmission of pain impulses via inhibition of noradrenaline and serotonin re-uptake and also by weakly binding to mu-opioid receptors.
How its work
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Tramadol may work as a pain blocker and may have a very mild antidepressant benefit. Alternatives include non-medication modalities, pain interventions and other medications that may work in a similar manner.
Tramadol has become a standard analgesic for the treatment of moderate to moderately-severe or severe pain; it is a stronger alternative to NSAIDS and an alternative to lower-dose morphine. Scheduling of tramadol would restrict its legitimate therapeutic use and worsen the existing under treatment of pain.
Thus given the already minimal levels of abuse, scheduling tramadol will have little or no impact on abuse and will only increase the potential for harming patients. The nature of the increased potential harm comes from
1) continued under treatment of pain;
2) increased use of NSAIDS;
3) increased use of potent opioids.
This would invert the concept of balancing benefit and risk and undermine the precautionary principle.
Tramadol has demonstrated therapeutic usefulness in the treatment of moderate to moderately-severe or severe pain, e.g. in postoperative and post-traumatic pain, cancer pain, and pain associated with chronic benign diseases. Tramadol’s efficacy overlaps with low doses of morphine.
Classical side effects of morphine-like drugs such as constipation, respiratory depression and sedation are reduced with tramadol.
Studies
=========
Studies of tramadol extended-release tablets suggest that in addition to relief from pain and improved function, additional benefits of fewer interruptions in sleep and improved compliance may occur. Thus, tramadol is an effective and safe drug for the treatment of pain. As such, tramadol is a unique tool for filling the analgesic gap that exists between NSAIDs and potent prototypic opioids.
================
Tramadol is a centrally acting synthetic analgesic of the aminocyclohexanol group with opioid-like effects. Its mode of action is not completely understood but it appears to act by modifying transmission of pain impulses via inhibition of noradrenaline and serotonin re-uptake and also by weakly binding to mu-opioid receptors.
How its work
============
Tramadol may work as a pain blocker and may have a very mild antidepressant benefit. Alternatives include non-medication modalities, pain interventions and other medications that may work in a similar manner.
Tramadol has become a standard analgesic for the treatment of moderate to moderately-severe or severe pain; it is a stronger alternative to NSAIDS and an alternative to lower-dose morphine. Scheduling of tramadol would restrict its legitimate therapeutic use and worsen the existing under treatment of pain.
Thus given the already minimal levels of abuse, scheduling tramadol will have little or no impact on abuse and will only increase the potential for harming patients. The nature of the increased potential harm comes from
1) continued under treatment of pain;
2) increased use of NSAIDS;
3) increased use of potent opioids.
This would invert the concept of balancing benefit and risk and undermine the precautionary principle.
Tramadol has demonstrated therapeutic usefulness in the treatment of moderate to moderately-severe or severe pain, e.g. in postoperative and post-traumatic pain, cancer pain, and pain associated with chronic benign diseases. Tramadol’s efficacy overlaps with low doses of morphine.
Classical side effects of morphine-like drugs such as constipation, respiratory depression and sedation are reduced with tramadol.
Studies
=========
Studies of tramadol extended-release tablets suggest that in addition to relief from pain and improved function, additional benefits of fewer interruptions in sleep and improved compliance may occur. Thus, tramadol is an effective and safe drug for the treatment of pain. As such, tramadol is a unique tool for filling the analgesic gap that exists between NSAIDs and potent prototypic opioids.
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